The most common side effects of Ozempic include nausea, vomiting, diarrhoea, constipation, and an upset stomach, especially during the first few weeks when the body is adjusting. These side effects often get better over time. Rare but serious side effects can include pancreatitis, gallbladder problems, and in some cases low blood sugar (hypoglycemia), especially when combined with other diabetes medications. It is important to report any side effects to your healthcare provider.